What Is The Makeup Of Perfume
Many products list "fragrance" on the label, but very few name the specific ingredients that make up a "fragrance." This lack of disclosure prevents consumers from knowing the full list of ingredients in their products. While most fragrance chemicals are non disclosed, we do know that some are linked to serious wellness bug such as cancer, reproductive and developmental toxicity, allergies and sensitivities. Clearly, in that location is a demand for stronger regulations, more research, and greater transparency.
Establish IN:Most personal intendance products including sunscreen, shampoo, lather, trunk launder, deodorant, body lotion, makeup, facial foam, skin toner, serums, exfoliating scrubs and perfume.
WHAT TO Look FOR ON THE Characterization:Fragrance, perfume, parfum, essential oil alloy, aroma.
WHAT IS FRAGRANCE?Fragrance is defined by the FDA as a combination of chemicals that gives each perfume or cologne (including those used in other products) its singled-out scent. Fragrance ingredients may be derived from petroleum or natural raw materials. Companies that manufacture perfume or cologne buy fragrance mixtures from fragrance houses (companies that specialize in developing fragrances) to develop their own proprietary blends. In improver to "odour" chemicals that create the fragrance, perfumes and colognes besides contain solvents, stabilizers, UV-absorbers, preservatives, and dyes. More than...
These additives are frequently, but not always, listed on product labels. In contrast, the chemical components in fragrance itself are protected as trade secrets and described on the label but as "fragrance."
In other personal care products, fragrances that are added also include the combination of ingredients that give the production a odour and that stabilize the scent. These are typically only indicated by the term "fragrance" or "parfum."
HEALTH CONCERNS: The International Fragrance Association (IFRA) lists 3,059 materials that are reported every bit being used in fragrance compounds. [1] Of these iii,059 ingredients, some have evidence linking them to health effects including cancer, reproductive toxicity, allergies and sensitivities.
A 2016 study assessed self-reported health effects from fragrance. This survey of a random sample of The states residents plant that 99.1% of participants are exposed to fragranced products at least once a week from their own utilize, others' use, or both. Participants too reported an extensive list of health effects experienced when exposed to fragrance ranging from migraines and asthma to gastrointestinal issues and cardiovascular problems. The findings showed that a loftier percent of the participants did not know of the chemicals included in fragrance and would not continue to use a fragranced production if they had previously known information technology emitted pollutants. [ii]
Acetaldehyde: Acetaldehyde adversely affects kidneys and the reproductive, nervous and respiratory systems. [3] This chemical is listed as known or suspected to crusade cancer in California's Proffer 65. [four] Both the International Agency for Research on Cancer and the National Toxicology Program classify acetaldehyde as potentially carcinogenic to humans. [5] , [vi]
Benzophenone:Benzophenone is linked to endocrine disruption and organ system toxicity, [7] and experimental studies suggest benzophenone may lead to several kinds of tumors. [eight] Derivatives of benzophenone, such as benzophenone-i (BP-one) and oxybenzone (BP-3), are potential endocrine disruptors. [9] Benzophenone is listed every bit a possible human carcinogen under California'south Suggestion 65. [ten] MORE...
Butylated hydroxyanisole (BHA): Studies demonstrating BHA's potential to disrupt endocrine functioning led the European Commission on Endocrine Disruption to listing BHA as a Category 1 priority substance. [11] ,[12] This chemical is likewise listed as a carcinogen on California'due south Proffer 65. [13]
Butylated hydroxytoluene (BHT): BHT irritates the optics and skin and may adversely affect 1'due south growth rate and liver. [fourteen] The American Conference of Governmental Industrial Hygienists (ACGIH) has determined that at that place is moderate evidence that BHT is a homo respiratory irritant. [15]
Benzyl Salicylate:Benzyl salicylate is a fragrance allergen and a potential endocrine disruptor. [16] [17]The European union restricts its use and requires that it is listed on production labels. [18], [19]
Benzyl Benzoate: benzyl benzoate is a skin and eye irritant and may severely irritate, burn and sting the genitalia and scalp. [20] The European Union requires that it is listed individually on products and restricts quantity utilize. [21]
Butoxyethanol: Butoxyethanol is a skin, center, olfactory organ and throat irritant. Exposure can lead to blood in the urine, airsickness and nausea with long-term damage to the kidneys, liver, lymphoid organization, nervous system, respiratory organisation and claret cells. [22] Butoxyethanol is also a reproductive toxicant. The International Bureau for Inquiry on Cancer confirms the carcinogenicity of butoxyethanol in experimental animals. [23] Both the European Union and Canada restrict butoxyethanol in consumer products. [24], [25]
Butylphenyl methylpropional: Besides known past its brand name Lilial, butylphenyl methylpropionale is a scent chemic restricted in the European Union. [26] Its potential for dermal sensitization motivated the International Fragrance Association to besides restrict its use in fragrance products. [27]
Chloromethane (methyl chloride):Chloromethane can have both acute and chronic effects on the nervous system and besides adversely impacts the liver, kidneys and skin. [28]It is listed nether California's Proposition 65 as a developmental toxicant. [29]
Dichloromethane (methylene chloride):Dichloromethane is linked to mammary gland tumors in experimental animals [30] and may exist an occupational carcinogen. [31] It is reasonably predictable to exist a human carcinogen according to the National Toxicology Program [32]and peradventure carcinogenic to humans according to the International Agency for Enquiry on Cancer. [33] Its use in fragrance products is restricted by the European Commission and prohibited by the U.South. Nutrient and Drug Assistants. [34]
Diethyl phthalate (DEP):DEP is an irritant of optics, skin and the respiratory tract. Information technology is a potential endocrine disruptor and has been linked to reproductive and nervous system toxicity. [35],[36]
Essential Oil Mixtures: Despite being fragrance ingredients of 'natural origin,' some essential oils are allergens and their allergenicity is no different than synthetic fragrance ingredients. [37] The FDA treats essential oil ingredients the same every bit other personal care production ingredients. [38]The International Fragrance Bureau restricts citrus oils and other constitute-derived organic chemicals containing essential oils due to their phototoxic furnishings. [39]Essential oils may contain ingredients such equally pulegone or methyleugenol that may be carcinogenic and modify endocrine functioning. [40], [41], [42]
Eugenyl methyl ether (Methyleugenol): It can impact multiple endocrine systems [43] and induce mammary gland tumors in experimental animals. [44]Methyluegenol is a naturally occurring substance used in essential oils. It is a possible human carcinogen co-ordinate to California's Proposition 65, [45] the National Toxicology Program, [46] and the International Agency for Research on Cancer. [47]
Formaldehyde:Administrative entities on chemic hazards agree that formaldehyde is a known human carcinogen. [48], [49]It is banned in cosmetics and toiletries in Nippon and Sweden while the European Marriage and Canada restricts its utilise. [50], [51] California'due south Proposition 65 states that in its gas course, formaldehyde is a probable carcinogen. [52] In occupational settings, formaldehyde is a cancer risk and immune system sensitizer. [53]
MEA, DEA, TEA – ethanolamines:When ethanolamines are used in the same product equally certain preservatives that break downward into nitrogen, they can class nitrosamines. Nitrosamines are a class of more a dozen different chemicals, which the International Bureau for Inquiry on Cancer lists individually as possible and known carcinogens. [54] The National Toxicology Programme Study on Carcinogens lists xv individual nitrosamines equally reasonably anticipated human carcinogens. [55]
Methanol:Methanol is a developmental poisonous substance according to California's Proposition 65, [56] and the European Marriage has concentration restrictions of methanol in cosmetics. [57]
Oxybenzone (BP-iii):This UV-filter is a derivative of benzophenone and a potential endocrine disruptor. [58] Oxybenzone can accumulate in the claret, kidneys and liver and may be toxic to liver cells. [59], [60] The European Wedlock restricts oxybenzone at upwards to 10 per centum maximum concentration in cosmetics. [61]
Propyl paraben (Propyl p-hydroxybenzoate): Propyl paraben is a possible endocrine disruptor. [62] Denmark banned propyl paraben and other paraben forms in corrective products for children up to 3 years one-time, [63] which then motivated the European Committee to implement restrictions reducing the concentrations of propyl paraben in corrective products. [64]
Resorcinol:Resorcinol changes liver, kidney and spleen functioning and adversely affects the cardiovascular and nervous system. [65]The European Commission lists this chemical as a Category i endocrine disruptor, [66] and the European union restricts concentrations and requires labeling of products that comprise these chemicals. [67]In Japan, the course Resorcin is banned in all types of cosmetics. [68]
Styrene: Styrene tin can be toxic to red blood cells and the liver when taken orally and toxic to the key nervous system when inhaled. [69] It is reasonably anticipated to be a human carcinogen [70],[71]and is a Category 1 endocrine disruptor in living organisms according to the European Committee. [72]
Synthetic Musks (Tonalide , Galaxolide, Musk Ketone, Musk Xylene):These chemicals are used in fragrances and added to personal care products. Synthetic musks are highly bioaccumulative and have been detected in chest milk, torso fat, and the cord blood of newborn babies. [73], [74], [75], [76] Studies show that these compounds may disrupt hormone systems [77], [78], [79], [80], [81]and may be reproductive, [82], [83] development, [84], [85]and organ system toxicants. [86], [87]
Titanium dioxide (TiO2):Inhalation exposure tin can damage lungs and the respitory system. TiO2 may exist an occupational carcinogen [88]and is listed as carcinogenic on California's Proposition 65. [89] The International Agency for Research on Cancer as well lists this chemic equally a possible human being carcinogen. [90]
1,4-Dioxane:1,4-dioxane is a by-product of a process to make other chemicals less harsh. Considering it is a contaminant produced during manufacturing, the U.S. FDA does non crave 1,iv-dioxane to exist listed as an ingredient on product labels. However, this chemical is known or suspected to cause cancer or birth defects according to California's Proposition 65. [91]The International Agency for Inquiry on Cancer lists this chemical equally peradventure carcinogenic to humans while the National Toxicology Program categories 1,four-dioxane equally reasonably anticipated to be carcinogenic to humans. [92], [93]
Our own product testing revealed the presence of 2 chemicals ethylbenzene and vinyl acetate in products marketed to kids. These ingredients were not listed on labels, leading us to suspect they may have been used in fragrance. These chemicals are not on the IFRA list of fragrance ingredients, merely our 2016 report shows that these possible carcinogens could be lurking in personal care products and kids cosmetics. [94]
Ethylbenzene: Ethylbenzene is a volatile organic chemical compound that has been classified by the International Agency for Research on Cancer as a possible carcinogen. [95] Information technology is also listed on California'southward Suggestion 65 list of known carcinogens to cause cancer. [96] Ethylbenzene is mainly used in the industry of styrene. [97] It is also used as a solvent, as a constituent of asphalt and naphtha, and in fuels. [98] Short-term exposure may result in respiratory furnishings, such as throat irritation and chest constriction, irritation of the eyes, and other effects such equally dizziness. [99] Inhalation over fourth dimension has shown alien results regarding its effects on the blood. [100]
Vinyl acetate: Vinyl acetate is primarily used as a monomer in the production of polyvinyl acetate and polyvinyl alcohol. [101] It is also used as a raw material in the production of other chemicals, adhesives, water-based paints, nonwoven textile fibers, textile sizing's and finishes, paper coatings, inks, films, and lacquers. [102], [103] Vinyl acetate is listed by the International Agency for Research on Cancer as a possible carcinogen. [104] Brusque-term inhalation exposure has resulted in middle irritation and upper respiratory tract irritation. [105]
VULNERABLE POPULATIONS: All, especially pregnant women, infants
REGULATIONS:Current laws exercise not provide the FDA with the potency to require disclosure or public safety of fragrance ingredients. In the U.South., companies are required to listing ingredients on the label; nevertheless, this regulation excludes the individual constituents of fragrance in order to preserve fragrance trade secrets. This sustains a loophole that leads to disclosure gaps.
The International Fragrance Clan (IFRA) and the Research Institute for Fragrance Materials (RIFM) develop and gear up voluntary standards for chemicals in the "fragrance" component of products. The US, Canada, and Europe rely on IFRA and RIFM to place ingredients for utilize in fragrance. In effect, this means the international Fragrance industry is self-regulating.
HOW TO AVOID: Read labels and avoid products when no information is given other than "fragrance".
REFERENCES
[1] IFRA. IFRA Ingredients, 2015. Bachelor online:http://www.ifraorg.org/en-us/ingredients#.VW-Cdc-6eUk.
[2] Steinemann A. Fragranced consumer products: exposures and effects from emissions. Air Quality, Temper & Health. 2016:1-6.
[three] CDC. Acetaldehyde. NIOSH Pocket Guide to Chemical Hazards, 2015. Available online:http://www.cdc.gov/niosh/npg/npgd0001.html.
[4] California Proposition 65. Office of Environmental Health Hazard Assessment, 2015. Available online:http://oehha.ca.gov/prop65/prop65_list/Newlist.html.
[5] IARC. Re-evaluation of some organic chemicals, hydrazine and hydrogen peroxide. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol. 71, pp 99-106, 1999. Available online: http://publications.iarc.fr/89. Accessed online March 12, 2020.
[6] National Toxicology Program. Report on Carcinogens, Thirteenth Edition. U.Due south. Section of Health and Human Services, 2014. Available online:http://ntp.niehs.nih.gov/ntp/roc/content/listed_substances_508.pdf.
[7] OEHHA. Suggestion 65. CA.gov, 2015. Available onlinehttp://oehha.ca.gov/prop65/prop65_list/Newlist.html
[8] Rhodes MC., et al. Carcinogenesis studies of benzophenone in rats and mice. Food Chem Toxicol, vol. 45, no. 5, pp 843-851, 2007.
[9] Endocrine Disruption. TedX Listing of Potential Endocrine Disruptors. Available online: http://endocrinedisruption.org/popup-chemic-details?chemid=151.
[10] California Proposition 65. Office of Environmental Wellness Hazard Assessment, 2015. Available online:http://oehha.ca.gov/prop65/prop65_list/Newlist.html.
[11] European Commission on Endocrine Disruption. Annex 1 Candidate list of 553 substances. Available online:http://ec.europa.eu/environment/archives/docum/pdf/bkh_annex_01.pdf
[12] European Commission on Endocrine Disruption. Study on enhancing the Endocrine Disrupter priority list with a focus on low production volume chemic, 2007. Available online:http://ec.europa.eu/environment/chemicals/endocrine/pdf/final_report_2007.pdf
[13] California Proffer 65. Office of Ecology Health Risk Assessment, 2015. Available online:http://oehha.ca.gov/prop65/prop65_list/Newlist.html.
[14] CDC. Butylated Hydroxytoluene. NIOSH Pocket Guide to Chemical Hazards, 2014. Bachelor online:http://www.cdc.gov/niosh/npg/npgd0246.html
[xv] Environmental Working Group, "Skin Deep. Butylated Hydroxytoluene." Bachelor online:http://www.ewg.org/skindeep/ingredient/700741/BHT/. Accessed online June 20, 2013.
[16] European Commission. Opinion concerning fragrance allergy in consumers. Scientific Commission on Cosmetic Products and Not-Food Products Intended for Consumers, 1999. Available online:http://ec.europa.eu/health/ph_risk/committees/sccp/documents/out98_en.pdf.
[17] Charles AK, Darbre PD. 2009. Oestrogenic activeness of benzyl salicylate, benzyl benzoate and butylphenylmethylpropional (Lilial) in MCF7 human chest cancer cells in vitro. J Appl Toxicol. 29(5): 422-34.
[xviii] European Committee. Annex Iii. European Commission Health and Consumers. Bachelor online:http://ec.europa.eu/consumers/cosmetics/cosing/index.cfm?fuseaction=search.results&annex_v2=3&search.
[19] European Commission. Stance on fragrance allergens in corrective products. Scientific Committee on Consumer Safety, 2011. Available online:http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_073.pdf.
[20] National Center for Biotechnology Information. PubChem Database. Benzyl benzoate, CID=2345. Available online: https://pubchem.ncbi.nlm.nih.gov/compound/Benzyl-benzoate Accessed online March 12, 2020.
[21] European Committee. Addendum Three. European Commission Wellness and Consumers. Available online: http://ec.europa.european union/consumers/cosmetics/cosing/index.cfm?fuseaction=search.results&annex_v2=III&search.
[22] CDC. Butoxyethanol. NIOSH Pocket Guide to Chemical Hazards, 2015. Bachelor online:http://www.cdc.gov/niosh/npg/npgd0070.html.
[23] National Library of Medicine Databank on Chemical Effects. 2-Butoxyethanol. Hazmap, 2015. Bachelor online:http://hazmap.nlm.nih.gov/category-details?id=129&table=copytblagents.
[24] European Commission. Butoxyethanol. European Committee Health and Consumers. Bachelor online:http://ec.europa.european union/consumers/cosmetics/cosing/index.cfm?fuseaction=search.details&id=31696.
[25] Health Canada. Cosmetic Ingredient Hotlist. 2014. Available online:http://www.hc-sc.gc.ca/cps-spc/cosmet-person/hot-list-critique/hotlist-liste-eng.php#a1.
[26] European Marriage. Regulation (EC) NO 1223/2009 of the European Parliament and of the Council. Official Journal of the European Spousal relationship, 2009. Available online:http://eur-lex.europa.eu/LexUriServ/LexUriServ.exercise?uri=OJ:L:2009:342:0059:0209:en:PDF.
[27] IFRA. P-tert-Butyl-alpha-methylhydrocinnamic aldehyde (BMHCA). IFRA Standard, 2013. Available online: https://ifrafragrance.org/docs/default-source/ifra-code-of-practise-and-standards/ifra-standards—48th-amendment/23598_gd_2015_06_30_index_to_the_ifra_standards1f796446a5dc40ada8a60526e5542c09.pdf?sfvrsn=e90196f7_2.
[28] OSHA. Methyl Chloride. United States Section of Labor. Available online:https://www.osha.gov/dts/chemicalsampling/information/CH_252200.html.
[29] California Proposition 65. Office of Environmental Health Hazard Assessment, 2015. Bachelor online:http://oehha.ca.gov/prop65/prop65_list/Newlist.html.
[xxx] Silent Springs. Methylene Chloride. Mammary Carcinogens Reviews Database. Available online: http://sciencereview.silentspring.org/mamm_detail.cfm?cid=75-09-2.
[31] CDC. Methylene chloride. NIOSH Pocket Guide to Chemical Hazards, 2015. Bachelor online: http://www.cdc.gov/niosh/npg/npgd0414.html.
[32] National Toxicology Programme. Report on Carcinogens, Thirteenth Edition. U.Southward. Department of Health and Human Services, 2014. Bachelor online:http://ntp.niehs.nih.gov/ntp/roc/content/listed_substances_508.pdf.
[33] IARC. Agents Classified by the IARC Monographs, Volumes 1-112. Available online:http://monographs.iarc.fr/ENG/Classification/ClassificationsAlphaOrder.pdf
[34] U.South. FDA. Prohibited and Restricted Ingredients. U.S. Department of Health and Human Services, 2015. Available online:http://www.fda.gov/cosmetics/guidanceregulation/lawsregulations/ucm127406.htm#prohibited.
[35] Endocrine Disruption. TedX List of Potential Endocrine Disruptors. Available online:http://endocrinedisruption.org/popup-chemic-details?chemid=527.
[36] CDC. Diethyl phthalate. NIOSH Pocket Guide to Chemic Hazards, 2015. Bachelor online: http://world wide web.cdc.gov/niosh/npg/npgd0213.html.
[37] European Commission. Essential Oils. Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers, 2003. Available online:http://ec.europa.eu/health/ph_risk/committees/sccp/documents/out218_en.pdf.
[38] U.Southward. FDA. Aromatherapy. U.South. Department of Health and Human Services, 2015. Bachelor online: http://www.fda.gov/Cosmetics/ProductsIngredients/Products/ucm127054.htm#essentialoil.
[39] IFRA. IFRA Standards Library. Bachelor online:http://www.ifraorg.org/en-us/standards-library.
[40] California Proffer 65. Office of Environmental Health Hazard Assessment, 2015. Available online: http://oehha.ca.gov/prop65/prop65_list/Newlist.html.
[41] National Toxicology Program. NTP Technical Study on the Toxicology and Carcinogenesis Studies of pulegone in F344/N Rats and B6C3F1 Mice. National Constitute of Health, 2011. Available online:http://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr563.pdf.
[42] Henley D, Lipson N, Korach K, Bloch C. Prepubertal gynecomastia linked to lavender and tea tree oils. New England Journal of Medicine, vol. 356, pp 479-485, 2007.
[43] Dodson R, Nishioka M, Standley L, Perovich L, Brody J, Rudel R. Endocrine disruptors and asthma-associated chemicals in consumer products. Environ Health Perspect, vol. 120, no. vii, pp 935-943, 2012. Available online:http://world wide web.ncbi.nlm.nih.gov/pmc/articles/PMC3404651/.
[44] Silent Spring. methyleugenol. Mammary Carcinogens Reviews Database. Available online:http://sciencereview.silentspring.org/mamm_detail.cfm?cid=93-xv-2.
[45] California Proposition 65. Role of Environmental Wellness Risk Assessment, 2015. Available online: http://oehha.ca.gov/prop65/prop65_list/Newlist.html.
[46] National Toxicology Programme. Report on Carcinogens, Thirteenth Edition. U.S. Section of Health and Homo Services, 2014. Bachelor online:http://ntp.niehs.nih.gov/ntp/roc/content/listed_substances_508.pdf.
[47] IARC. Methyleugenol. IARC Monographs, 2012, volume 101, pp 407-433. Bachelor online:http://monographs.iarc.fr/ENG/Monographs/vol101/mono101-013.pdf
[48] National Toxicology Programme. Report on Carcinogens, Thirteenth Edition. U.S. Department of Wellness and Human Services, 2014. Available online:http://ntp.niehs.nih.gov/ntp/roc/content/listed_substances_508.pdf.
[49] IARC. Agents Classified by the IARC Monographs, Volumes 1–112 Available Online:http://monographs.iarc.fr/ENG/Nomenclature/ClassificationsAlphaOrder.pdf.
[l] Scientific Committee on Corrective Products and Non-food Products. Stance concerning a description on the formaldehyde and para-formaldehyde entry in Directive 76/768/EEC on corrective products. Opinion: European Commission. 2002. Bachelor online:https://ec.europa.eu/health/ph_risk/committees/sccp/documents/out187_en.pdf.
[51] Amparo S and Chisvert A, editors. Analysis of Cosmetic Products. Elsevier. Amsterdam. 2007. p. 215. – See more at:http://world wide web.safecosmetics.org/get-the-facts/chemicals-of-concern/formaldehyde/#sthash.4eJsYjUY.dpuf
[52] California Proposition 65. Office of Ecology Health Take chances Cess, 2015. Bachelor online: http://oehha.ca.gov/prop65/prop65_list/Newlist.html.
[53] OSHA. Formaldehyde Fact Sail. Available online:https://world wide web.osha.gov/OshDoc/data_General_Facts/formaldehyde-factsheet.pdf.
[54] IARC. Agents Classified by the IARC Monographs, Volumes one–112 Bachelor online:http://monographs.iarc.fr/ENG/Classification/ClassificationsAlphaOrder.pdf.
[55] Study on Carcinogens, Twelfth Edition (2011) Bachelor online:http://ntp.niehs.nih.gov/ntp/roc/twelfth/profiles/Nitrosamines.pdf.
[56] California Proffer 65. Role of Environmental Health Gamble Assessment, 2015. Available online:http://oehha.ca.gov/prop65/prop65_list/Newlist.html.
[57] European Commission. Annex III. European Committee Health and Consumers. Bachelor online:http://ec.europa.eu/consumers/cosmetics/cosing/index.cfm?fuseaction=search.results&annex_v2=III&search.
[58] Endocrine Disruption. TedX Listing of Potential Endocrine Disruptors. Available online: http://endocrinedisruption.org/popup-chemical-details?chemid=186.
[59] European Food Rubber Authority. Available online:http://www.efsa.europa.european union/en/efsajournal/pub/1104.htm.
[threescore] Fediuk DJ., Tissue disposition of the insect repellent DEET and the sunscreen oxybenzone following intravenous and topical assistants in rats. Biopharm Drug Dispos, vol. 32, no. 7, pp 369-79, 2011.
[61] European Committee. Bachelor online:http://ec.europa.eu/consumers/cosmetics/cosing/index.cfm?fuseaction=search.details_v2&id=28809.
[62] Endocrine Disruption. TedX List of Potential Endocrine Disruptors. Available online:http://endocrinedisruption.org/endocrine-disruption/tedx-list-of-potential-endocrine-disruptors/chemicalsearch?sname=&x=0&y=0&action=search&sall=i&searchfor=any&scas=94-13-three&searchcats=all.
[63] Danish Ministry building of the Environment-Environmental Protection Agency. Statutory order on restriction on import, sale and employ of certain parabens in corrective products for children under 3 years. Available online: http://eng.mst.dk/media/mst/Attachments/Engelskparabenbekendtgrelse.pdf.
[64] European Commission. Commission Regulation (Eu) No 1004/2014. Official Periodical of the European Union, 2014. Bachelor online:http://eur-lex.europa.european union/legal-content/EN/TXT/PDF/?uri=CELEX:32014R1004&rid=one.
[65] CDC. Resorcinol. NIOSH Pocket Guide to Chemical Hazards, 2015. Available online: http://www.cdc.gov/niosh/npg/npgd0543.html.
[66] European Commission on Endocrine Disruption. Addendum 1 Candidate list of 553 substances. Available online:http://ec.europa.european union/environment/archives/docum/pdf/bkh_annex_01.pdf
[67] European Committee. Annex III. European Committee Health and Consumers. Bachelor online:http://ec.europa.european union/consumers/cosmetics/cosing/index.cfm?fuseaction=search.results&annex_v2=III&search.
[68] Standards for Cosmetics. Ministry of Health and Welfare Notification No. 331. Bachelor online:http://www.mhlw.get.jp/english/dl/cosmetics.pdf.
[69] Ecology Protection Agency. Styrene. Integrated Risk Data Organisation, 2014. Available online: http://www.epa.gov/iris/subst/0104.htm.
[70] National Toxicology Program. Report on Carcinogens, Thirteenth Edition. U.South. Department of Health and Human Services, 2014. Available online:http://ntp.niehs.nih.gov/ntp/roc/content/listed_substances_508.pdf.
[71] IARC. Monographs on the evaluation of carcinogenic risks to humans. IARC Press, volume 82, 2002. Available online:http://monographs.iarc.fr/ENG/Monographs/vol82/mono82.pdf.
[72] European Commission. Addendum xiii. Listing of 146 substances with endocrine disruption classifications prepared in the Skilful meeting. Available online:http://ec.europa.eu/environment/athenaeum/docum/pdf/bkh_annex_13.pdf.
[73] Kang C, et al. Polybrominated diphenyl ethers and synthetic musk in umbilical cord serum, maternal serum, and breast milk from Seoul, South Korea. Chemosphere, vol. 80, pp 116-122, 2010.
[74] Zhang X, Jing Y, Ma L, Zhou J, Fang X, Zhang 10, Yu Y. Occurrence and ship of synthetic musks in paired maternal claret, umbilical cord, and chest milk. International Journal of Hygiene and Ecology Health, vol. 218, pp 99-106, 2015.
[75] Reiner J, Wong C, Arcano K, Kannan Grand. Synthetic musk fragrances in human milk from the United States. Environ. Sci. Technol., vol. 41, pp 3815-3820, 2007.
[76] Kannan Yard, Reiner J, Yun South, Perrotta E, Tao L, Johnson-Restrepo, Rodan B. Polycyclic musk compounds in higher trophic level aquatic organisms and humans from the United States. Chemosphere, vol. 61, pp 693-700, 2005.
[77] Petersen G, Tollefsen K. Assessing combined toxicity of estrogen receptor agonists in a primary of civilization of rainbow trout (Oncorhynchus mykiss) hepatocytes. Aquatic toxicology, vol. 101, pp 186-195, 2011.
[78] Witorsch R, Thomas J. Personal care products and endocrine disruption: a critical review of the literature. Critical Reviews in Toxicology, vol. 40, no. S3, pp 1-30, 2010.
[79] Schreurs R, Sonneveld E, Jansen J, Seinen W, van der Burg B. Interaction of polycyclic musks and UV filters with the estrogen receptor (ER), androgen receptor (AR), and progesterone receptor (PR) in reporter cistron bioassays. Toxicological Sciences, vol. 83, pp 264-272, 2005.
[80] Bitsch N, Dudas C, Körner W, Failing K, Biselli Due south, Rimkus G, Brunn H. 2002. Estrogenic action of musk fragrances detected by the E-screen assay using human mcf-7 cells. Curvation Environ Contam Toxicol. 43(3): 257-64. – See more at:http://www.safecosmetics.org/get-the-facts/chemicals-of-business concern/constructed-musks/#sthash.YG1w1dBn.dpuf
[81] Endocrine Disruption. TedX List of Potential Endocrine Disruptors. Available online: http://endocrinedisruption.org/popup-chemical-details?chemid=613.
[82] Eisenhardt S, Runnebaum B, Bauer K, Gerhard I. Nitromusk compounds in women with gynecological and endocrine dysfunction. Environmental Research Section A, vol. 87, pp 123-130, 2001.
[83] Carlsson G, Om S, Andersson P, Soderstrom H, Norrgren L. The impact of musk ketone on reproduction in zebrafish (Danio rerio). Marine Environmental Inquiry, vol. fifty, no. ane-five, pp 237-241, 2000.
[84] Shi J, Li M, Jiao Z, Zhang J, Fend Y, Shao B. Microarray analysis of gene expression in mouse (strain 129) embryonic stem cells afterward typical synthetic musk exposure. Bull Environ Contam Toxicol, vol. 90, pp 17-21, 2013.
[85] Wollenberger L, Breitholtz M, Kusk Yard, Bengtsson B. Inhibition of larval development of the marine copepod Acartia tonsa past four synthetic musk substances. Scientific discipline of the Total Environment, vol. 305, no. ane-3, pp 53-64, 2003.
[86] Ayuk-Takem Fifty, Amissah F, Aguilar B, Lamango Northward. Inhibition of polyisoprenylated methylated protein methyl esterase by synthetic musks induces jail cell degeneration. Environmental Toxicology, vol. 29, no. four, pp 466-477, 2014.
[87] Schnell Due south, Bols N, Barata C, Porte C. Single and combined toxicity of pharmaceuticals and personal care products (PPCPs) on the rainbow trout liver cell line RTL-W1. Aquatic toxicology, vol. 93, no. 4, pp 244-252, 2009.
[88] CDC. Titanium Dioxide. NIOSH Pocket Guide to Chemical Hazards, 2015. Available online:http://www.cdc.gov/niosh/npg/npgd0617.html.
[89] California Proposition 65. Function of Environmental Wellness Take a chance Assessment, 2015. Bachelor online:http://oehha.ca.gov/prop65/prop65_list/Newlist.html.
[xc] IARC. Agents Classified by the IARC Monographs, Volumes ane-112. Bachelor online:http://monographs.iarc.fr/ENG/Nomenclature/ClassificationsAlphaOrder.pdf.
[91] California Suggestion 65. Office of Environmental Health Hazard Assessment, 2015. Available online:http://oehha.ca.gov/prop65/prop65_list/Newlist.html.
[92] IARC. i,iv-Dioxane. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, 1999, vol. 71, supplement vii, pp 589-602. Available online:http://monographs.iarc.fr/ENG/Monographs/vol71/mono71-25.pdf.
[93] National Toxicology Plan. Report on Carcinogens, Thirteenth Edition. U.S. Department of Health and Human Services, 2014. Available online:http://ntp.niehs.nih.gov/ntp/roc/content/listed_substances_508.pdf.
[94] Engel C, Nudelman MA, Rasanayagam South, Witte M. Pretty Scary 2 Unmasking toxic chemicals in kids' makeup. Campaign for Safety Cosmetics. 2016 October. Available online:https://d124kohvtzl951.cloudfront.cyberspace/wp-content/uploads/2017/03/02025306/Report_Pretty-Scary_October_2009.pdf.
[95] IARC: International Agency for Research on Cancer. Agents classified past the IARC Monographs, Volumes 1-112, 2015. Available online: http://monographs.iarc.fr/ENG/Classification/ClassificationsAlphaOrder.pdf
[96] California Proffer 65. Office of Ecology Health Take chances Assessment, 2016. Available online: http://oehha.ca.gov/media/downloads/proposition-65//p65single10212016.pdf
[97] EPA: Environmental Protection Agency. Ethylbenzene. Air Toxics Web Site, 2000. Available online: https://www.epa.gov/sites/production/files/2014-03/documents/ethylbenzene_toxfaqstfacts110_3v.pdf
[98] Bureau for Toxic Substances and Disease Registry (ATSDR). Toxicological Profile for Ethylbenzene (Update). Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA. 1999.
[99] EPA: Environmental Protection Agency. Ethylbenzene. Air Toxics Web Site, 2000. Available online: https://www.epa.gov/sites/production/files/2014-03/documents/ethylbenzene_toxfaqstfacts110_3v.pdf
[100] EPA: Environmental Protection Agency. Ethylbenzene. Air Toxics Web Site, 2000. Available online: https://www.epa.gov/sites/product/files/2014-03/documents/ethylbenzene_toxfaqstfacts110_3v.pdf
[101] Agency for Toxic Substances and Affliction Registry (ATSDR). Toxicological Profile for Vinyl Acetate. U.S. Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA. 1992.
[102] Agency for Toxic Substances and Affliction Registry (ATSDR). Toxicological Profile for Vinyl Acetate. U.S. Public Health Service, U.South. Department of Health and Human Services, Atlanta, GA. 1992.
[103] EPA: Ecology Protection Agency. Vinyl Acetate. Air Toxics Web Site, 2000. Available online: https://www.epa.gov/sites/production/files/2016-09/documents/vinyl-acetate.pdf
[104] IARC: International Bureau for Research on Cancer. Agents classified past the IARC Monographs, Volumes 1-112, 2015. Bachelor online: http://monographs.iarc.fr/ENG/Nomenclature/ClassificationsAlphaOrder.pdf
[105] Agency for Toxic Substances and Illness Registry (ATSDR). Toxicological Contour for Vinyl Acetate. U.South. Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA. 1992.
Source: https://www.safecosmetics.org/get-the-facts/chemicals-of-concern/fragrance/
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